Metformin increases hepatic leptin receptor and decreases steatosis in mice
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چکیده
منابع مشابه
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2(-/-) mice) both have severe insulin resistance, diabetes mellitus, hepatic steatosis, and low plasma leptin levels. In this study, we show that continuous le...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2016
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-16-0142